Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill.

Histone-Associated Thrombocytopenia in Patients WhoAre Critically Ill Thrombocytopenia is observed in approximately 30% to 40% of patients in the intensive care unit (ICU) and associated with poor outcomes. Histones induce profound thrombocytopenia in mice1,2 and are associated with organ injury when released following extensive cell damage in patients who are critically ill.3,4 We explored the association between circulating histones and thrombocytopenia in patients in the ICU.